Research Paper Volume 11, Issue 17 pp 6960—6982
TPM2 as a potential predictive biomarker for atherosclerosis
- 1 Neurology Department, Beijing Hospital, National Center of Gerontology, Beijing 100730, P. R. China
- 2 Graduate School, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P. R. China
- 3 Anesthesiology Department, Beijing Hospital, National Center of Gerontology, Beijing 100730, P. R. China
- 4 The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, P. R. China
- 5 Department of Neurology, Peking University First Hospital, Beijing 100034, P. R. China
- 6 Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang Development Zone, Hebei 050011, P.R. China
- 7 School of Basic Medicine, Peking University, Beijing 100191, P. R. China
received: July 20, 2019 ; accepted: August 18, 2019 ; published: September 5, 2019 ;https://doi.org/10.18632/aging.102231
How to Cite
Copyright © 2019 Meng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cardiac-cerebral vascular disease (CCVD), is primarily induced by atherosclerosis, and is a leading cause of mortality. Numerous studies have investigated and attempted to clarify the molecular mechanisms of atherosclerosis; however, its pathogenesis has yet to be completely elucidated. Two expression profiling datasets, GSE43292 and GSE57691, were obtained from the Gene Expression Omnibus (GEO) database. The present study then identified the differentially expressed genes (DEGs), and functional annotation of the DEGs was performed. Finally, an atherosclerosis animal model and neural network prediction model was constructed to verify the relationship between hub gene and atherosclerosis. The results identified a total of 234 DEGs between the normal and atherosclerosis samples. The DEGs were mainly enriched in actin filament, actin binding, smooth muscle cells, and cytokine-cytokine receptor interactions. A total of 13 genes were identified as hub genes. Following verification of animal model, the common DEG, Tropomyosin 2 (TPM2), was found, which were displayed at lower levels in the atherosclerosis models and samples. In summary, DEGs identified in the present study may assist clinicians in understanding the pathogenesis governing the occurrence and development of atherosclerosis, and TPM2 exhibits potential as a promising diagnostic and therapeutic biomarker for atherosclerosis.