Research Paper Volume 11, Issue 18 pp 7587—7604
Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults
- 1 Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
- 2 Division of Biostatistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
- 3 Department of Physical Activity and Health, Eastern Oregon University, La Grande, OR 97850, USA
received: June 29, 2019 ; accepted: September 5, 2019 ; published: September 14, 2019 ;https://doi.org/10.18632/aging.102273
How to Cite
Copyright © 2019 Hart et al. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 3.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sarcopenia is linked with impaired adaptive responses to exercise in aging skeletal muscle. The unfolded protein response (UPR) is an important intramyocellular molecular response pathway that is activated by exercise. The influence of age on skeletal muscle adaptive UPR in response to exercise, and the relationship to other key exercise-responsive regulatory pathways is not well-understood. We evaluated age-related changes in transcriptional markers of UPR activation following a single bout of resistance exercise in 12 young (27 ± 5yrs) and 12 older (75 ± 5yrs) healthy men and women. At baseline, there were modest differences in expression of UPR-related genes in young and older adults. Following exercise, transcriptional markers of UPR pathway activation were attenuated in older adults compared to young based on specific salient UPR-related genes and gene set enrichment analysis. The coordination of post-exercise transcriptional patterns between the UPR pathway, p53/p21 axis of autophagy, and satellite cell differentiation were less evident in older compared to young adults. In conclusion, transcriptomic analysis revealed an age-related decline in the adaptive UPR transcriptional response following a single bout of exercise that could contribute to impaired exercise responsiveness with age.