Research Paper Volume 11, Issue 20 pp 9147—9166
Dysfunctional interactions between the default mode network and the dorsal attention network in subtypes of amnestic mild cognitive impairment
- 1 School of Psychology, Capital Normal University, Beijing Key Laboratory of Learning and Cognition, Beijing, China
- 2 Department of Psychology, Tsinghua University, Beijing, China
- 3 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
- 4 Department of Radiology, Aerospace Center Hospital, Beijing, China
- 5 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China
received: July 19, 2019 ; accepted: October 14, 2019 ; published: October 24, 2019 ;https://doi.org/10.18632/aging.102380
How to Cite
Copyright © 2019 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
An anticorrelated relationship in the spontaneous fluctuations between the default mode network (DMN) and dorsal attention network (DAN) is a robust feature of intrinsic brain organization in healthy individuals. Prior studies have reported a decreased anticorrelation between the DMN and the DAN in Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, it is unclear how this anticorrelation changes as MCI progresses to AD. We hypothesized that dysfunctional connectivity between the DMN and DAN may reflect the gradual decline from MCI to AD. To test this hypothesis, we investigated alterations in functional connectivity between the DMN and DAN in subtypes of amnestic MCI (aMCI) by comparing with the same functional pattern in healthy elderly individuals and patients with AD. We retrospectively collected brain imaging and neuropsychological data from 20 AD participants, 22 participants with multiple-domain aMCI (aMCI-m), 29 participants with single-domain aMCI (aMCI-s) and 23 sex-matched normal controls in this study. Resting-state functional connectivity analysis revealed that aMCI-s and aMCI-m groups demonstrated different magnitudes of increased anticorrelation between the DMN and DAN relative to the AD group. Furthermore, in aMCI-s, aMCI-m and AD participants, hypoconnectivity was found in specific regions within the DMN, including the precuneus and angular gyrus, and hyperconnectivity was found in areas outside the typical DMN networks, including the middle occipital gyrus, lingual gyrus and visual cortex, which indicated disease-related adaptations of brain networks. Our findings suggest that DMN-DAN anticorrelation may shed light on the understanding of the adaptations in brain function during the progression from MCI to AD and may serve as a potential biomarker to detect AD in the preclinical stage.