COVID-19 Research Paper Volume 12, Issue 7 pp 6049—6057

Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis

Bolin Wang1, , Ruobao Li2, , Zhong Lu3, , Yan Huang3, ,

  • 1 Weifang Medical University, Weifang 261031, China
  • 2 Department of Human Anatomy, Weifang Medical University, Weifang 261031, China
  • 3 Department of Oncology, Affiliated Hospital of Weifang Medical University, Weifang 261031, China

Received: March 12, 2020       Accepted: March 28, 2020       Published: April 8, 2020
How to Cite

Copyright © 2020 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Currently, the number of patients with coronavirus disease 2019 (COVID-19) has increased rapidly, but relationship between comorbidity and patients with COVID-19 still not clear. The aim was to explore whether the presence of common comorbidities increases COVID-19 patients’ risk. A literature search was performed using the electronic platforms (PubMed, Cochrane Library, Embase, and other databases) to obtain relevant research studies published up to March 1, 2020. Relevant data of research endpoints in each study were extracted and merged. All data analysis was performed using Stata12.0 software. A total of 1558 patients with COVID-19 in 6 studies were enrolled in our meta-analysis eventually. Hypertension (OR: 2.29, P<0.001), diabetes (OR: 2.47, P<0.001), chronic obstructive pulmonary disease (COPD) (OR: 5.97, P<0.001), cardiovascular disease (OR: 2.93, P<0.001), and cerebrovascular disease (OR:3.89, P=0.002)were independent risk factors associated with COVID-19 patients. The meta-analysis revealed no correlation between increased risk of COVID-19 and liver disease, malignancy, or renal disease. Hypertension, diabetes, COPD, cardiovascular disease, and cerebrovascular disease are major risk factors for patients with COVID-19. Knowledge of these risk factors can be a resource for clinicians in the early appropriate medical management of patients with COVID-19.


COVID-19: coronavirus disease 2019; 2019-nCoV: 2019 novel coronavirus; COPD: chronic obstructive pulmonary disease.

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