Research Paper Volume 12, Issue 8 pp 7397—7410
c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis
- 1 The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
- 2 Guangzhou Blood Center, Guangzhou, Guangdong, China
- 3 Lianjiang People’s Hospital, Lianjiang, Guangdong, China
- 4 St. George and Sutherland Clinical School, University of New South Wales, Kogarah, NSW, Australia
- 5 Department of Haematology, St. George Hospital, Kogarah, NSW, Australia
- 6 Department of Pulmonary and Critical Care Medicine, Shenzhen People’s Hospital, Shenzhen, Guangdong, China
Received: November 11, 2019 Accepted: April 13, 2020 Published: April 27, 2020https://doi.org/10.18632/aging.103086
How to Cite
Copyright © 2020 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Thrombopoietin (TPO) is a growth factor for the megakaryocytic/platelet lineage. In this study, we investigated the expression of TPO and its receptor, c-Mpl, in the human central nervous system (CNS) and their roles after a neural insult. Our results demonstrate that both TPO and c-Mpl are expressed in the neurons of the human CNS. TPO was also detected in human cerebrospinal fluid. TPO was found to be neuroprotective in hypoxic-ischemic neonatal rat brain models. In these rat models, treatment with TPO reduced brain damage and improved sensorimotor functions. In addition, TPO promoted C17.2 cell proliferation through activation of the PI3K/Akt signaling pathway. Via the Bcl-2/BAX signaling pathway, TPO exerted an antiapoptotic effect by suppressing mitochondrial membrane potentials. Taken together, our results indicate that TPO is neuroprotective in the CNS.