Research Paper Volume 12, Issue 11 pp 10676—10686
Modelling biological age based on plasma peptides in Han Chinese adults
- 1 Department of Epidemiology and Health Statistics, School of Public Health, Beijing Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing 100069, China
- 2 The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, China
- 3 Beijing Neurosurgical Institute, Beijing 100070, China
- 4 School of Medical and Health Sciences, Edith Cowan University, Perth 6027, Australia
- 5 School of Public Health, Shandong First Medical University and Academy of Medical Sciences of Shandong Province, Tai’an 271016, China
Received: December 6, 2019 Accepted: April 27, 2020 Published: June 5, 2020https://doi.org/10.18632/aging.103286
How to Cite
Copyright © 2020 Cao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Age-related disease burdens increased over time, and whether plasma peptides can be used to accurately predict age in order to explain the variation in biological indicators remains inadequately understood. Here we first developed a biological age model based on plasma peptides in 1890 Chinese Han adults. Based on mass spectrometry, 84 peptides were detected with masses in the range of 0.6-10.0 kDa, and 13 of these peptides were identified as known amino acid sequences. Five of these thirteen plasma peptides, including fragments of apolipoprotein A-I (m/z 2883.99), fibrinogen alpha chain (m/z 3060.13), complement C3 (m/z 2190.59), complement C4-A (m/z 1898.21), and breast cancer type 2 susceptibility protein (m/z 1607.84) were finally included in the final model by performing a multivariate linear regression with stepwise selection. This biological age model accounted for 72.3% of the variation in chronological age. Furthermore, the linear correlation between the actual age and biological age was 0.851 (95% confidence interval: 0.836-0.864) and 0.842 (95% confidence interval: 0.810-0.869) in the training and validation sets, respectively. The biological age based on plasma peptides has potential positive effects on primary prevention, and its biological meaning warrants further investigation.