Research Paper Volume 12, Issue 11 pp 11071—11084
LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK
- 1 Department of Radiotherapy, People's Hospital of Shanxi Province, Taiyuan, China
- 2 Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China
- 3 Department of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou, China
Received: February 24, 2020 Accepted: April 28, 2020 Published: June 10, 2020https://doi.org/10.18632/aging.103321
How to Cite
Copyright © 2020 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Long non-coding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis, for example, in hepatocellular carcinoma (HCC). This study explored the role of LINC01419, a new lncRNA, in HCC. In vitro study revealed that LINC01419 promotes growth and migration of HCC cells. Genes that affected cell proliferation and cell migration were identified using RNA-sequence. Subsequently, it was confirmed that LINC01419 binds to EZH2, leading to histone methylation of the RECK promoter. Interaction between LINC01419 and FUS stabilized EZH2 mRNA thereby enhancing EZH2 expression. Conclusively, the results of this study confirm that LINC01419 may serve as a potential target for HCC diagnosis and treatment.