Elena Colicino1Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Riccardo Marioni2Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK, Cavin Ward-Caviness3,US Environmental Protection Agency, Chapel Hill, NC 27514, USA33Institute for Epidemiology II, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg D-85764, Germany, Rahul Gondalia4Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA, Weihua Guan5Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA, Brian Chen6Longitudinal Study Section, Translational Gerontology Branch, National Institute of Aging, Bethesda, MD 20892, USA, Pei-Chien Tsai7Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK, Tianxiao Huan8National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA, Gao Xu9Columbia University Mailman School of Public Health, New York, NY 10032, USA, Agha Golareh9Columbia University Mailman School of Public Health, New York, NY 10032, USA, Joel Schwartz10Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA, Pantel Vokonas11VA Boston Healthcare System and Boston University Schools of Public Health and Medicine, Boston, MA 02115, USA, Allan Just1Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, John M. Starr12Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK, Allan F. McRae13Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia, Naomi R. Wray13Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia, Peter M. Visscher13Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia, Jan Bressler14University of Texas Health Science Center at Houston, Houston, TX 77030, USA, Wen Zhang15Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA, Toshiko Tanaka6Longitudinal Study Section, Translational Gerontology Branch, National Institute of Aging, Bethesda, MD 20892, USA, Ann Zenobia Moore6Longitudinal Study Section, Translational Gerontology Branch, National Institute of Aging, Bethesda, MD 20892, USA, Luke C. Pilling16Epidemiology and Public Health Group, University of Exeter Medical School, Exeter, UK, Guosheng Zhang17Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA, James D. Stewart4Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA, Yun Li4Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA, Lifang Hou18Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA, Juan Castillo-Fernandez7Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK, Tim Spector7Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK, Douglas P. Kiel19Hebrew SeniorLife Institute for Aging Research and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School Boston, MA 02215, USA, Joanne M. Murabito20Section General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02215, USA, Chunyu Liu21Boston University School of Public Health, Boston, MA 02215, USA, Mike Mendelson22Boston University School of Medicine, Boston, MA 02215, USA, Tim Assimes23Stanford University School of Medicine, Stanford, CA 94305, USA, Devin Absher24Hudson Alpha Institute for Biotechnology, Huntsville, AL 35806, USA, Phil S. Tsaho25Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA, Ake T. Lu25Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA, Luigi Ferrucci26National Institute of Aging, Bethesda, MD 20892, USA, Rory Wilson27Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg D-85764, Germany, Melanie Waldenberger27Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg D-85764, Germany, Holger Prokisch28Institute of Human Genetics, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg S-85764, Germany, Stefania Bandinelli29Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy, Jordana T. Bell7Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK, Daniel Levy30Framingham Heart Study, Framingham, MA 01702, USA, Ian J. Deary31Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK, Steve Horvath25Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA, Jim Pankow32Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA, Annette Peters33Institute for Epidemiology II, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg D-85764, Germany, Eric A. Whitsel4Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA, Andrea Baccarelli9Columbia University Mailman School of Public Health, New York, NY 10032, USA
- 1Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
- 2Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
- 3US Environmental Protection Agency, Chapel Hill, NC 27514, USA
- 4Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA
- 5Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
- 6Longitudinal Study Section, Translational Gerontology Branch, National Institute of Aging, Bethesda, MD 20892, USA
- 7Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK
- 8National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
- 9Columbia University Mailman School of Public Health, New York, NY 10032, USA
- 10Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
- 11VA Boston Healthcare System and Boston University Schools of Public Health and Medicine, Boston, MA 02115, USA
- 12Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK
- 13Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
- 14University of Texas Health Science Center at Houston, Houston, TX 77030, USA
- 15Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
- 16Epidemiology and Public Health Group, University of Exeter Medical School, Exeter, UK
- 17Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA
- 18Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
- 19Hebrew SeniorLife Institute for Aging Research and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School Boston, MA 02215, USA
- 20Section General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02215, USA
- 21Boston University School of Public Health, Boston, MA 02215, USA
- 22Boston University School of Medicine, Boston, MA 02215, USA
- 23Stanford University School of Medicine, Stanford, CA 94305, USA
- 24Hudson Alpha Institute for Biotechnology, Huntsville, AL 35806, USA
- 25Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
- 26National Institute of Aging, Bethesda, MD 20892, USA
- 27Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg D-85764, Germany
- 28Institute of Human Genetics, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg S-85764, Germany
- 29Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy
- 30Framingham Heart Study, Framingham, MA 01702, USA
- 31Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK
- 32Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
- 33Institute for Epidemiology II, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg D-85764, Germany
* First authors
# Last authors
