Research Paper Volume 12, Issue 14 pp 14569—14581
High serum uric acid is associated with increased arterial stiffness in hypertension
- 1 Department of Geriatrics, Shanghai First People’s Hospital Affiliated to Nanjing Medical University, Shanghai 200080, China
- 2 Department of Cardiology, Shidong Hospital of Shanghai Yangpu, Shanghai 200433, China
- 3 Department of Neurology, School of Clinical Medicine, Dali University, YunNan 671000, China
- 4 Community Health Service Center, Shanghai 200435, China
- 5 Community Health Service Center, Shanghai 201914, China
- 6 Department of Neurology, No.908 Hospital of the People's Liberation Army Joint Logistics Support Force, JiangXi 330000, China
- 7 Department of Cardiology, Changhai Hospital, Naval Military Medical University, Shanghai 200433, China
- 8 Department of Radiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
- 9 Department of Emergency, Shanghai First People's Hospital Affiliated to Nanjing Medical University, Shanghai 200080, China
Received: March 9, 2020 Accepted: June 4, 2020 Published: July 23, 2020https://doi.org/10.18632/aging.103506
How to Cite
Copyright © 2020 An et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Serum uric acid level has been found to be associated with cerebrovascular diseases. However, whether serum uric acid level is a risk factor for arterial stiffness in the hypertension population is unclear. This study was designed to determine the relationship between serum uric acid level and arterial stiffness in the hypertension population. A total of 10450 participants were evaluated for the risk of arterial stiffness. Brachial-ankle pulse wave velocity (baPWV) was assessed, and high baPWV was determined as the highest quartile of baPWV values in a sex-specific manner. We evaluated the association between serum uric acid level and baPWV through multivariate-adjusted linear and logistic regression analyses. There was a significant difference on high baPWV between patients with quartiles of serum uric acid level in females and males (p<0.01), respectively. The odds ratios (95% CI) of the highest baPWV quartile across the sex-specific serum uric acid level were 1.0, 1.71 (1.35, 2.17), 1.75 (1.38, 2.23), and 1.95 (1.51, 2.51) in female, and 1.0, 1.33 (1.09, 1.64), 1.36 (1.11, 1.67), and 1.67 (1.36, 2.04) in male after adjusting for potential confounders. In conclusion, serum uric acid level could be considered as an important risk factor for arterial stiffness in Chinese hypertension population.