Research Paper Volume 12, Issue 17 pp 17393—17417
Physical performance and chronic kidney disease development in elderly adults: results from a nationwide cohort study
- 1 Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul 03722, Republic of Korea
- 2 Division of Nephrology, Department of Internal Medicine, Myongji Hospital, Goyang 10475, Gyeonggi-do, Republic of Korea
- 3 Severance Biomedical Science Institute, Brain Korea 21 PLUS, Yonsei University, Seoul 03722, Republic of Korea
- 4 Division of Nephrology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea
Received: April 3, 2020 Accepted: July 7, 2020 Published: September 11, 2020https://doi.org/10.18632/aging.103741
How to Cite
Copyright: © 2020 Joo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sarcopenia, which is characterized by muscle mass and physical performance, is closely associated with morbidities and mortality, especially among the elderly. However, the effect of physical performance on chronic kidney disease (CKD) development is not yet fully elucidated. A total of 30,871 adults aged 66 years with preserved renal function who underwent health screening examinations were evaluated. Physical performance was assessed using a 3-m timed up and go (TUG) test and the one-leg stand (OLS) test. The primary outcome was the development of CKD, defined as at least two consecutive measurements of estimated glomerular filtration rate < 60 mL/min/1.73 m2. The rates of mortality and incident CKD development were significantly elevated with increases in TUG test scores but not in OLS scores. In the Cox hazards model, the highest TUG test score tertile was associated with an increased risk for CKD development (hazard ratio, 1.23; 95% confidence interval, 1.10-1.38) compared with the lowest tertile. No significant relationship was observed between OLS score and incident CKD risk. Poor physical performance, assessed using the TUG test, was related to an increased risk of CKD development.