COVID-19 Research Paper Volume 12, Issue 17 pp 16675—16689
Clinical course and risk factors for recurrence of positive SARS-CoV-2 RNA: a retrospective cohort study from Wuhan, China
- 1 Department of Cardiothoracic Surgery, Naval Medical Center of PLA, Shanghai 200052, People’s Republic of China
- 2 Department of Infectious Disease, Guanggu Branch of Hubei Province Maternity and Childcare Hospital, Hubei 430073, People’s Republic of China
- 3 Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, People’s Republic of China
- 4 Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Naval Military Medical University, Shanghai 200438, People’s Republic of China
Received: June 2, 2020 Accepted: July 14, 2020 Published: September 10, 2020https://doi.org/10.18632/aging.103795
How to Cite
Copyright: © 2020 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The objective of this study was to determine the clinical course and risk factors for patients showing recurrent SARS-CoV-2 RNA positivity. A total of 1087 COVID-19 patients confirmed by RT-PCR from February 24, 2020 to March 31, 2020 were retrospectively enrolled. Advanced age was significantly associated with mortality. In addition, 81 (7.6%) of the discharged patients tested positive for SARS-CoV-2 RNA during the isolation period. For patients with recurrent RT-PCR positivity, the median duration from illness onset to recurrence was 50 days. Multivariate regression analysis identified elevated serum IL-6, increased lymphocyte counts and CT imaging features of lung consolidation during hospitalization as the independent risk factors of recurrence. We hypothesized that the balance between immune response and virus toxicity may be the underlying mechanism of this phenomenon. For patients with a high risk of recurrence, a prolonged observation and additional preventative measures should be implemented for at least 50 days after illness onset to prevent future outbreaks.