Research Paper Volume 12, Issue 24 pp 25005—25019
Sleep quality and risk of coronary heart disease - a prospective cohort study from the English longitudinal study of ageing
- 1 Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
- 2 Department of Environmental and Occupational Health, West China School of Public Health, Sichuan University, Chengdu, China
Received: May 30, 2020 Accepted: July 21, 2020 Published: November 16, 2020
https://doi.org/10.18632/aging.103866How to Cite
Abstract
Background: The association between sleep quality and risk of coronary heart disease (CHD) remains unclear in the elderly.
Results: At eight-year follow up, a total of 411 (4.29%) participants developed CHD. Compared with good quality group, the multivariable hazard ratio [HR] (95% confidence interval [CI]) for CHD was 1.393 (1.005, 1.931) for intermediate quality group and 1.913 (1.206, 3.035) for poor quality group. Consistent results were observed in participants with normal sleep duration.
Conclusions: Poor sleep quality may be a novel modifiable risk factor for CHD in the elderly independent of conventional cardiovascular risk factors, even when sleep duration was normal.
Methods: The current study included 9570 CHD-free participants in the English Longitudinal Study of Ageing (ELSA) from wave 4 (2008 to 2009). Incident CHD included new onset angina or myocardial infarction. Sleep quality was measured by a four-item questionnaire. Score ranged from 1 (best) to 4 (poorest). Participants were divided into three groups: good quality (1 ≤ score <2), intermediate quality (2 ≤ score <3) and poor quality (3 ≤ score ≤4). Cox regression model was used to calculate HR for CHD risk according to sleep quality, adjusted for conventional CHD risk factors and sleep duration.
Abbreviations
CHD: coronary heart disease; HR: hazard ratio; CI: confidence interval; ELSA: English longitudinal study of ageing; BMI: body mass index; NS-SEC: National Statistics-Socio Economic Classification; CES-D: Centre for Epidemiological Studies Depression scale.