Review Volume 12, Issue 18 pp 18765—18777
Psychological aging, depression, and well-being
- 1 Deep Longevity, Inc., Three Exchange Square, The Landmark, Hong Kong, China
- 2 Longevity Vision Fund, New York, NY 10022, USA
- 3 Insilico Medicine, Hong Kong Science and Technology Park (HKSTP), Hong Kong, China
- 4 The Buck Institute for Research on Aging, Novato, CA 94945, USA
Received: May 23, 2020 Accepted: July 25, 2020 Published: September 18, 2020https://doi.org/10.18632/aging.103880
How to Cite
Copyright: © 2020 Mitina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aging is a multifactorial process, which affects the human body on every level and results in both biological and psychological changes. Multiple studies have demonstrated that a lower subjective age is associated with better mental and physical health, cognitive functions, well-being and satisfaction with life. In this work we propose a list of non-modifiable and modifiable factors that may possibly be influenced by subjective age and its changes across an individual’s lifespan. These factors can be used for a future development of individual psychological aging clocks, which may be utilized as a sensitive measure for health status and overall life satisfaction. Furthermore, recent progress in artificial intelligence and biomarkers of biological aging have enabled scientists to discover and evaluate the efficacy of potential aging- and disease-modifying drugs and interventions. We propose that biomarkers of psychological age, which are just as important as those for biological age, may likewise be used for these purposes. Indeed, these two types of markers complement one another. We foresee the development of a broad range of parametric and deep psychological and biopsychological aging clocks, which may have implications for drug development and therapeutic interventions, and thus healthcare and other industries.