Research Paper Volume 12, Issue 24 pp 24709—24720
Post-transplant colitis after kidney transplantation: clinical, endoscopic and histological features
- 1 General Surgery Unit, University Hospital of Catania, Catania 95123, Italy
- 2 Pathology Unit, Department of Medical and Surgical Sciences and Advanced Technologies, University of Catania, Catania 95123, Italy
- 3 Organ Transplant Unit, University Hospital of Catania, Catania 95123, Italy
- 4 Department of Biomedical and Biotechnological Sciences, University of Catania, Catania 95123, Italy
- 5 Gastroenterology Unit, University Hospital of Catania, Catania 95123, Italy
Received: October 10, 2020 Accepted: November 16, 2020 Published: December 22, 2020https://doi.org/10.18632/aging.202345
How to Cite
Copyright: © 2020 Gioco et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Chronic immunosuppression may increase the risk of post-transplant infection and medication-related injury and may also be responsible for the increased risk of gastrointestinal complications in kidney transplant recipients. Differentiating the various forms of post-transplant colitis is challenging, since most have similar clinical and histological features. This study evaluated the incidence of post-transplant gastrointestinal complications during screening colonoscopy. Kidney transplant recipients undergoing a colonoscopy for any reasons in the period 2014-2018 were included. Among the 134 patients completing the colonoscopy, 74 patients (56%) had an abnormal finding: an adenoma was found in 25 patients (18.6%), while 19 patients (14.1%) had colitis. Mycophenolic acid/related colitis was the most common colitis (6%), while 7 patients (5.2%) developed a de novo inflammatory bowel disease. Patients with post-transplant colitis were younger and with shorter time from transplant compared to patients without colitis. In conclusions, immunosuppression may predispose kidney transplant recipients to an increased risk of post-transplant colitis. Diagnostic colonoscopy should be encouraged in all transplant patients with refractory diarrhea and gastrointestinal symptoms to allow a prompt diagnosis and a timely treatment, finally improving the quality of life and long-term outcomes of affected patients.