Research Paper Volume 13, Issue 1 pp 1410—1421

Prognostic and clinical significance of modified glasgow prognostic score in pancreatic cancer: a meta-analysis of 4,629 patients

Dongdong Wu1, , Xingmu Wang1, , Ge Shi1, , Honggang Sun1, , Guoxing Ge1, ,

  • 1 Clinical Laboratory Center, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang, China

Received: July 6, 2020       Accepted: October 5, 2020       Published: January 6, 2021
How to Cite

Copyright: © 2020 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


In this study, we evaluated the association of modified Glasgow Prognostic Score (mGPS) with prognosis in pancreatic cancer (PC) by performing a meta-analysis. Potentially eligible studies were shortlisted by searching PubMed, Embase, Web of Science, Scopus, and the Cochrane Library. A total of 4,629 patients with PC from 25 studies were finally included in this meta-analysis. Meta-analyses were performed using a random-effects model or fixed-effect model according to heterogeneity. We pooled the hazard ratios (HRs) with 95% confidence intervals (CIs) to estimate the association between mGPS and overall survival (OS). The results showed that elevated mGPS correlated with poor OS in patients with PC (HR=1.92, 95% CI=1.60–2.30, p<0.002). In addition, subgroup analysis indicated that increased mGPS remained a significant prognostic factor irrespective of the study design, region, disease status, treatment, survival analysis, cancer type, study center, or the Newcastle-Ottawa Scale (NOS) score (all p<0.05). There was a significant correlation between higher mGPS and male gender (Odds ratio [OR]=1.30, 95% CI=1.01–1.67, p=0.038). Elevated pretreatment mGPS is a marker of poor prognosis in patients with PC. As an easily available and cost-effective inflammatory parameter, mGPS can serve as a promising tool for prognostication in PC.


mGPS: modified Glasgow Prognostic Score; PC: pancreatic cancer; HRs: hazard ratios; CIs: confidence intervals; OS: overall survival; NOS: Newcastle-Ottawa Scale; MSI: microsatellite instability; CRP: C-reactive protein; MeSH: medical subject heading; UVA: univariate analysis; MVA: multivariate analysis; TNM: Tumor Node Metastasis; REM: random-effects model; FEM: fixed-effects model; PDAC: pancreatic ductal adenocarcinoma; OR: odds ratio.