Research Paper Volume 13, Issue 4 pp 5250—5262
Clinical application values of neutrophil-to-lymphocyte ratio in intracranial aneurysms
- 1 Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
- 2 Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
- 3 China National Clinical Research Center for Neurological Diseases, Beijing 100070, China
- 4 Department of Information Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
- 5 Department of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China
Received: June 9, 2020 Accepted: November 10, 2020 Published: February 1, 2021https://doi.org/10.18632/aging.202445
How to Cite
Copyright: © 2021 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Inflammation plays an important role in the pathogenesis and growth of intracranial aneurysms (IAs). We investigated the clinical value of the neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic subclinical inflammation in patients with IAs.
Consecutive patients with IAs who underwent endovascular treatment (EVT) were enrolled in the study. The evaluation indicators were aneurysm size and rupture, a poor outcome at 3 to 6 months, and delayed cerebral ischemia (DCI) during hospitalization.
In total, 532 patients with IAs underwent EVT (mean age, 54.0 years; 62.4% female). Among patients with ruptured IAs, those with a higher NLR had an increased risk of a poor outcome at 3 to 6 months and DCI during hospitalization than those with a lower NLR. A higher NLR was significantly more strongly associated with the size of unruptured aneurysms and aneurysm rupture than a lower NLR. The NLR and C-reactive protein concentration showed similar predictive ability for aneurysm size and treatment prognosis. The NLR was lower at discharge than admission for patients with ruptured IAs and DCI.
An elevated NLR was significantly associated with the size of unruptured IAs, an increased risk of a poor outcome, and DCI in patients with ruptured IAs.