Review Volume 13, Issue 5 pp 7691—7706

β cell aging and age-related diabetes

Min Zhu1, , Xiaohong Liu1, , Wen Liu1, , Yanrong Lu1, , Jingqiu Cheng1,2, , Younan Chen1,2, ,

  • 1 Key Laboratory of Transplant Engineering and Immunology, NHFPC, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, P.R. China
  • 2 Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, P.R. China

Received: October 23, 2020       Accepted: December 23, 2020       Published: March 3, 2021
How to Cite

Copyright: © 2021 Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Type 2 diabetes is characterized by insulin resistance and loss of β cell mass and function. Aging is considered as a major risk factor for development of type 2 diabetes. However, the roles of pancreatic β cell senescence and systemic aging in the pathogenesis of type 2 diabetes in elderly people remain poorly understood. In this review, we aimed to discuss the current findings and viewpoints focusing on β cell aging and the development of type 2 diabetes.


AGEs: Advanced glycation end products; Arx: Aristaless-related homeobox; ATF6: Activating transcription factor 6; BAX: BCL2 associated X, apoptosis regulator; Bcl-2: B cell leukemia/lymphoma 2; ER: Endoplasmic reticulum; FoxO1: Forkhead box O1; GATA4: GATA binding protein 4; GATA6: GATA binding protein 6; GSIS: Glucose stimulated insulin secretion; IAPP: Islet amyloid polypeptide; IGF1R: Insulin like growth factor 1 receptor; JNK: c-Jun N-terminal kinase; MafA: v-Maf musculoaponeurotic fibrosarcoma oncogene homologue A; PDX-1: Pancreatic and duodenal homeobox 1; ROS: Reactive oxygen species; SASP: Senescence-associated secretory phenotype; Sox9: Sex-determining Region Y (SRY) box 9; STZ: Streptozotocin; T1D: Type 1 Diabetes; T2D: Type 2 Diabetes; UPR: Unfolded protein response.