Research Paper Volume 13, Issue 4 pp 6171—6181
Gene expression barcode values reveal a potential link between Parkinson’s disease and gastric cancer
- 1 Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, Jilin, P.R. China
- 2 Center for Applied Statistical Research, School of Mathematics, Jilin University, Changchun 130012, Jilin, P.R. China
- 3 Department of Thoracic Surgery I, First Hospital of Jilin University, Changchun 130021, Jilin, P.R. China
- 4 Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington , KY 40536, USA
- 5 Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
Received: October 12, 2020 Accepted: January 22, 2021 Published: February 16, 2021
https://doi.org/10.18632/aging.202623How to Cite
Copyright: © 2021 Tian et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Gastric cancer is a disease that develops from the lining of the stomach, whereas Parkinson’s disease is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. Although these two diseases seem to be distinct from each other, increasing evidence suggests that they might be linked. To explore the linkage between these two diseases, differentially expressed genes between the diseased people and their normal controls were identified using the barcode algorithm. This algorithm transforms actual gene expression values into barcode values comprised of 1’s (expressed genes) and 0’s (silenced genes). Once the overlapped differentially expressed genes were identified, their biological relevance was investigated. Thus, using the gene expression profiles and bioinformatics methods, we demonstrate that Parkinson’s disease and gastric cancer are indeed linked. This research may serve as a pilot study, and it will stimulate more research to investigate the relationship between gastric cancer and Parkinson’s disease from the perspective of gene profiles and their functions.