Research Paper Volume 13, Issue 9 pp 12395—12409

Expression and prognosis analyses of BUB1, BUB1B and BUB3 in human sarcoma

Zeling Long1, , Tong Wu1, , Qunyan Tian1, , Luke A. Carlson2, , Wanchun Wang1, , Gen Wu1, ,

  • 1 Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
  • 2 University of Pittsburgh, Pittsburgh, PA 15260, USA

Received: February 4, 2021       Accepted: March 27, 2021       Published: April 19, 2021
How to Cite

Copyright: © 2021 Long et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Budding Uninhibited By Benzimidazoles are a group of genes encoding proteins that play central roles in spindle checkpoint during mitosis. Improper mitosis may lead to aneuploidy which is found in many types of tumors. As a key mediator in mitosis, the dysregulated expression of BUBs has been proven to be highly associated with various malignancies, such as leukemia, gastric cancer, breast cancer, and liver cancer. However, bioinformatic analysis has not been applied to explore the role of the BUBs in sarcomas. Herein, we investigate the transcriptional and survival data of BUBs in patients with sarcomas using Oncomine, Gene Expression Profiling Interactive Analysis, Cancer Cell Line Encyclopedia, Kaplan-Meier Plotter, LinkedOmics, and the Database for Annotation, Visualization and Integrated Discovery. We found that the expression levels of BUB1, BUB1B and BUB3 were higher in sarcoma samples and cell lines than in normal controls. Survival analysis revealed that the higher expression levels of BUB1, BUB1B and BUB3 were associated with lower overall and disease-free survival in patients with sarcomas. This study implies that BUB1, BUB1B and BUB3 are potential treatment targets for patients with sarcomas and are new biomarkers for the prognosis of sarcomas.


BUB: Budding Uninhibited By Benzimidazoles; APC/C: Anaphase-Promoting Complex/Cyclosome; AURKB: Aurora Kinase B; GEPIA: Gene Expression Profiling Interactive Analysis; CCLE: Cancer Cell Line Encyclopedia; DAVID: Database for Annotation, Visualization and Integrated Discovery; KEGG: Kyoto Encyclopedia of Genes and Genomes; GO: Gene ontology; DEGs: Different expressed genes.