Research Paper Volume 13, Issue 9 pp 13138—13152
Circular RNA circitga7 accelerates glioma progression via miR-34a-5p/VEGFA axis
- 1 The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan 511518, Guangdong, China
- 2 Department of Pathophysiology, Jilin Medical University, Jilin 132013, Jilin, China
- 3 Department of Pathology, Jilin Medical University, Jilin 132013, China
- 4 Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, China
- 5 Department of Neurovascular, First Hospital of Jilin University, Changchun 130021, China
- 6 Department of Oncological Neurosurgery, First Hospital of Jilin University, Changchun 130021, China
Received: May 2, 2020 Accepted: October 8, 2020 Published: May 7, 2021https://doi.org/10.18632/aging.202996
How to Cite
Copyright: © 2021 Qi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Circular RNAs (circRNAs) are a group of noncoding RNAs derived from back-splicing events. CircRNA is reported to be involved in various tumor progressions, including glioma. Although there are a few reports of circular RNAs participating in gliomas, it is still unclear whether circular RNAs regulate the occurrence of gliomas. In our research, we found that the expression of circITGA7 in glioma tissues and glioma cells increased significantly. Knocking down circITGA7 can significantly inhibit the proliferation of glioma cells and reduce cell metastasis. Through analysis and dual-luciferase report assay, we found that circITGA7 acts as a sponge for miR-34a-5p targeting VEGFA in glioma. Our study showed that circITGA7 regulates the proliferation and metastasis of glioma cell lines (SW1783&U373) by regulating the miR-34a-5p/VEGFA pathway. In conclusion, our study revealed a regulatory loop for the circITGA7/miR-34a-5p/VEGFA axis to regulate glioma development.