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Research Paper|Volume 13, Issue 9|pp 13138—13152

Circular RNA circitga7 accelerates glioma progression via miR-34a-5p/VEGFA axis

Ling Qi1,2, Weiyao Wang1,2, Guifang Zhao1,3, Hong Jiang4, Yu Zhang5, Donghai Zhao3, Hong Jin3, Hongquan Yu6, Haiyang Xu6
  • 1The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan 511518, Guangdong, China
  • 2Department of Pathophysiology, Jilin Medical University, Jilin 132013, Jilin, China
  • 3Department of Pathology, Jilin Medical University, Jilin 132013, China
  • 4Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, China
  • 5Department of Neurovascular, First Hospital of Jilin University, Changchun 130021, China
  • 6Department of Oncological Neurosurgery, First Hospital of Jilin University, Changchun 130021, China
Received: May 2, 2020Accepted: October 8, 2020Published: May 7, 2021
https://doi.org/10.18632/aging.202996

Copyright: © 2021 Qi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Circular RNAs (circRNAs) are a group of noncoding RNAs derived from back-splicing events. CircRNA is reported to be involved in various tumor progressions, including glioma. Although there are a few reports of circular RNAs participating in gliomas, it is still unclear whether circular RNAs regulate the occurrence of gliomas. In our research, we found that the expression of circITGA7 in glioma tissues and glioma cells increased significantly. Knocking down circITGA7 can significantly inhibit the proliferation of glioma cells and reduce cell metastasis. Through analysis and dual-luciferase report assay, we found that circITGA7 acts as a sponge for miR-34a-5p targeting VEGFA in glioma. Our study showed that circITGA7 regulates the proliferation and metastasis of glioma cell lines (SW1783&U373) by regulating the miR-34a-5p/VEGFA pathway. In conclusion, our study revealed a regulatory loop for the circITGA7/miR-34a-5p/VEGFA axis to regulate glioma development.