Research Paper Volume 13, Issue 11 pp 14768—14784
Subclinical vasculopathy and skeletal muscle metrics in the singapore longitudinal ageing study
- 1 Department of Cardiology, National University Heart Center, Singapore
- 2 Geriatric Education and Research Institute, Singapore
- 3 Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
- 4 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
- 5 Department of Cardiology, National Heart Center, Singapore
- 6 Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School Singapore, Singapore
- 7 Cardiovascular Research Institute, National University Heart Center, Singapore
- 8 Christchurch Heart Institute, University of Otago, New Zealand
- 9 Faculty of Health and Social Sciences, Singapore Institute of Technology, Singapore
Received: January 6, 2021 Accepted: May 24, 2021 Published: June 7, 2021https://doi.org/10.18632/aging.203142
How to Cite
Copyright: © 2021 Lim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Frailty is associated with future cardiovascular events in older adults. This cross-sectional study examined the relationship between subclinical vasculopathy with measures of skeletal muscle mass and function. Asymptomatic community-dwelling Asians ≥55 years underwent assessments for subclinical vasculopathy (carotid intima-media thickness (cIMT), aortic and carotid stiffness, and endothelial function), muscle mass (calf circumference adjusted for body mass index) and function (knee extension strength, 6-meter fast gait speed). Multivariable regression analyses for associates of muscle mass/function controlled for demographics and cardiometabolic risk factors. Among 336 participants (median age 62 years, 55.1% male, 3.6% sarcopenia), cIMT, aortic and carotid stiffness inversely correlated with muscle mass, strength and gait speed; cIMT remained independently associated with gait speed (β=-0.26) in multivariable analyses. Age and sex significantly modified the relationship between subclinical vasculopathy and muscle mass/function. Associations, only found in those aged ≥70, included cIMT with gait speed (β=-0.48) and knee strength (β=-9.33), and aortic augmentation index and aortic stiffness composite z-score with gait speed (β=-0.11 and β=-0.19 respectively). Among males, cIMT correlated with gait speed (β=-0.31). The association of subclinical vasculopathy with skeletal muscle mass and function in asymptomatic adults ≥55 years is best reflected by cIMT. The roles of mediating pathways deserve further evaluation.