Research Paper Volume 13, Issue 19 pp 22856—22866
Retrospective analysis of renal prognosis in elderly coronary artery disease patients complicated with renal insufficiency
- 1 Department of Nephrology, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu, China
- 2 Research Center, Wuxi Institute of Technology, Wuxi 214121, Jiangsu, China
- 3 Department of Cardiology, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu, China
Received: November 24, 2020 Accepted: September 10, 2021 Published: October 4, 2021https://doi.org/10.18632/aging.203579
How to Cite
Copyright: © 2021 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective and Methods: The aim of this study was to retrospectively analyze the renal prognosis of elderly coronary artery disease (CAD) patients complicated with renal insufficiency.
Results: A total of 307 patients were included. The mean follow-up period was 25±11months. The average age was 79±7 years. In the worsening renal function group, there were higher occurrence rate of heart failure and severe coronary artery stenosis, lower rate of percutaneous coronary intervention, lower medication rate of renin-angiotensin blocker, lower plasma albumin, magnesium and hemoglobulin level. There was no significant difference in the rate of worsening renal function or gastrointestinal bleeding between patients who took anti-platelet agents/statins and those without. Patients with reduced left ventricular ejective fraction had higher rate of worsening renal function, yet lower medication rate of renin-angiotensin blockers, lower plasma albumin and hemoglobulin level. Anemia, malnutrition and worsening cardiac function were risk factors of renal function deterioration and mortality.
Conclusions: In the elderly coronary artery disease patients who had renal insufficiency, antiplatelet agents and statin have non-adverse effects on renal function; lower medication rate of renin-angiotensin blocker were found in patients with either worsening renal function or heart failure. Anemia, malnutrition and worsening cardiac function are risk factors of renal function deterioration and mortality.