Theory Article Volume 13, Issue 19 pp 23407—23415
Iron: an underrated factor in aging
- 1 MTOR LLC, Bakersfield, CA 93311, USA
Received: September 12, 2021 Accepted: September 27, 2021 Published: October 6, 2021https://doi.org/10.18632/aging.203612
How to Cite
Copyright: © 2021 Mangan. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Iron is an essential element for virtually all living organisms, but its reactivity also makes it potentially harmful. Iron accumulates with aging, and is associated with many age-related diseases; it also shortens the lifespans of several model organisms. Blocking iron absorption through drugs or natural products extends lifespan. Many life-extending interventions, such as rapamycin, calorie restriction, and old plasma dilution can be explained by the effects they have on iron absorption, excretion, and metabolism. Control of body iron stores so that they remain in a low normal range may be an important, lifespan- and healthspan-extending intervention.