Research Paper Volume 13, Issue 20 pp 23603—23619

Resveratrol promotes axonal regeneration after spinal cord injury through activating Wnt/β-catenin signaling pathway

Zimin Xiang1,2,3, *, , Shuai Zhang1,2,3, *, , Xiaodong Yao1,2,3, , Libin Xu1,2,3, , Jianwei Hu1,2,3, , Chenghui Yin1,2,3, , Jianmei Chen1,2,3, , Hao Xu1,2,3, ,

  • 1 Department of Orthopaedics, The 900th Hospital, Joint Logistics Support Force, Fuzhou 350025, Fujian Province, P.R. China
  • 2 Department of Orthopaedics, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, Fujian Province, P.R. China
  • 3 Department of Orthopaedics, Xiamen University Affiliated East Hospital Affiliated East Hospital, Fuzhou 350025, Fujian Province, P.R. China
* Equal contribution

Received: June 1, 2021       Accepted: August 3, 2021       Published: October 14, 2021
How to Cite

Copyright: © 2021 Xiang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Spinal cord injury (SCI) is characterized by autonomic dysreflexia, chronic pain, sensory and motor deficits. Resveratrol has shown potential neuroprotective function in several neurodegenerative diseases’ models. However, if resveratrol could improve the function recovery after SCI and the further mechanism have not been investigated.

Methods: SCI rat model was established through laminectomy at lamina T9-10 aseptically. Basso, beattie and bresnahan (BBB) and inclined plane score, sensory recovery, spinal cord content, and inflammatory factors were measured. The levels of GAP43, NF421, GFAP, Bax, Bcl-2 and caspase-3 were measured using immunohistochemical staining. Tunel staining was applied to detect apoptosis level.

Results: Resveratrol significantly improved the function recovery, promoted axonal regeneration, suppressed apoptosis after SCI. The activation of Wnt/β-catenin signaling pathway was achieved by resveratrol. XAV939 significantly reversed the influence of resveratrol on function recovery, axonal regeneration, apoptosis after SCI.

Conclusions: Resveratrol could promote the function recovery and axonal regeneration, improve histological damage, inhibit apoptosis level after SCI through regulating Wnt/β-catenin signaling pathway. This research expanded the regulatory mechanism of resveratrol in SCI injury.


SCI: Spinal cord injury; HE: Hematoxylin and eosin; BBB: Basso, beattie and bresnahan.