Research Paper Volume 14, Issue 7 pp 3175—3190
Burden of lymphoma in China, 1990−2019: an analysis of the global burden of diseases, injuries, and risk factors study 2019
- 1 Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Cancer Hospital and Institute, Beijing, China
- 2 National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
- 3 Beijing Institute of Survey and Mapping, Beijing Municipal Key Laboratory of Urban Spatial Information Engineering, Beijing, China
- 4 Department of Hematology and Oncology, Harbin Institute of Hematology and Oncology, Harbin, China
Received: November 27, 2021 Accepted: March 25, 2022 Published: April 10, 2022
https://doi.org/10.18632/aging.204006How to Cite
Copyright: © 2022 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: China is facing an aggravating disease burden of lymphoma. However, accurate information about lymphoma burden at the national and provincial levels is limited.
Results: The estimated number of disability-adjusted life years were 86,171.85 for Hodgkin lymphoma and 1,306,247.77 for non-Hodgkin lymphoma with the age-standardized rates of 4.95 and 71.00, respectively, per 100,000 population. There were estimated 9,468 new cases and 2,709 Hodgkin lymphoma-related deaths, and 91,954 new cases and 44,310 non-Hodgkin lymphoma-related deaths. Older individuals had a higher lymphoma burden. The age-standardized disability-adjusted life year rate in men was approximately two-folds higher than that in women. Moreover, disparities in lymphoma burden were observed across the provinces. Between 1990 and 2019, the disability-adjusted life year number decreased by 57.8% for Hodgkin lymphoma, and increased by 100.9% for non-Hodgkin lymphoma.
Conclusion: Burden of lymphoma showed heterogeneous change patterns varied according to sex, age, and provinces, with a steady decrease in Hodgkin lymphoma and a significant increase in non-Hodgkin lymphoma during the past three decades.
Methods: Following the analytical strategy used in the Global Burden of Diseases, Injuries, and Risk Factors Study 2019, age-, sex-, and province-specific incidence, mortality, and prevalence of Hodgkin lymphoma and non-Hodgkin lymphoma were analyzed. Lymphoma burden was assessed by incidence, mortality, prevalence, and disability-adjusted life year.
Abbreviations
ASIR: age-standardized incidence rates; ASMR: age-standardized mortality rates; DALYs: disability-adjusted life-years; GBD: Global Burden of Diseases, Injuries, and Risk Factors; HL: Hodgkin lymphoma; NHL: non-Hodgkin lymphoma; OS: overall survival; SDI: sociodemographic index; UI: uncertainty interval.