Research Paper Volume 16, Issue 18 pp 12593—12607
Study of the role of leukocyte telomere length-related lncRNA NBR2 in Alzheimer’s disease
- 1 Department of Geriatrics, The First Affiliated Hospital of Ningbo University, Ningbo 315000, China
- 2 Department of Geriatrics, Jiangsu Key Laboratory of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China
- 3 Department of Radiology of the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China
Received: March 16, 2024 Accepted: July 17, 2024 Published: September 16, 2024
https://doi.org/10.18632/aging.206107How to Cite
Copyright: © 2024 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Alzheimer’s Syndrome (AD) is a neurodegenerative disease that is prevalent in middle-aged and elderly people. As the disease progresses, patients gradually lose the ability to take care of themselves, which brings a heavy burden to the family. There is a link between leukocyte telomere length (LTL) and cognitive ability. To search for possible pathogenic mechanisms and potential therapeutic agents, we demonstrated a causal link between LTL and AD using Mendelian randomization analysis (MR). The expression of the target gene NBR2 and the downstream mRNA GJA1 and GJA1-related genes, pathway enrichment, and association with immune cells were further explored. Using the gene cluster-drug target interaction network, we obtained potential therapeutic drugs. Our study provides evidence for a causal link between AD and LTL, suggesting medicines that may treat and alleviate AD symptoms.