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Research Paper|Volume 16, Issue 20|pp 12955—12976

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Yu-Xuan Lyu1,2, Qiang Fu3,4,5, Dominika Wilczok6,125, Kejun Ying7, Aaron King8, Adam Antebi2,9, Aleksandar Vojta10, Alexandra Stolzing11, Alexey Moskalev12, Anastasia Georgievskaya13, Andrea B. Maier14, Andrea Olsen15, Anja Groth16, Anna Katharina Simon17,18, Anne Brunet19, Aisyah Jamil20, Anton Kulaga21,126, Asif Bhatti22, Benjamin Yaden23, Bente Klarlund Pedersen24, Björn Schumacher25, Boris Djordjevic26,27, Brian Kennedy14, Chieh Chen28,29, Christine Yuan Huang30, Christoph U. Correll31,32, Coleen T. Murphy33,34, Collin Y. Ewald35, Danica Chen36,37,38, Dario Riccardo Valenzano39, Dariusz Sołdacki40, David Erritzoe41, David Meyer25, David A. Sinclair42, Eduardo Nunes Chini43, Emma C. Teeling44, Eric Morgen45, Eric Verdin46, Erik Vernet47, Estefano Pinilla48, Evandro F. Fang49, Evelyne Bischof50, Evi M. Mercken51, Fabian Finger52, Folkert Kuipers53, Frank W. Pun54, Gabor Gyülveszi55, Gabriele Civiletto56, Garri Zmudze57, Gil Blander58, Harold A. Pincus59, Joshua McClure60, James L. Kirkland61, James Peyer62, Jamie N. Justice63, Jan Vijg64, Jennifer R. Gruhn65, Jerry McLaughlin66, Joan Mannick67, João Passos68, Joseph A. Baur69, Joe Betts-LaCroix70, John M. Sedivy71, John R. Speakman72, Jordan Shlain73, Julia von Maltzahn74, Katrin I. Andreasson75, Kelsey Moody76, Konstantinos Palikaras77, Kristen Fortney45, Laura J. Niedernhofer78, Lene Juel Rasmussen79, Liesbeth M. Veenhoff53, Lisa Melton80, Luigi Ferrucci81, Marco Quarta82,83,84, Maria Koval85, Maria Marinova86, Mark Hamalainen87, Maximilian Unfried14,88, Michael S. Ringel89, Milos Filipovic90, Mourad Topors91, Natalia Mitin92, Nawal Roy93, Nika Pintar94, Nir Barzilai95, Paolo Binetti48, Parminder Singh46, Paul Kohlhaas96, Paul D. Robbins97, Paul Rubin45, Peter O. Fedichev98, Petrina Kamya99, Pura Muñoz-Canoves100, Rafael de Cabo101, Richard G. A. Faragher102, Rob Konrad103, Roberto Ripa2, Robin Mansukhani104, Sabrina Büttner105, Sara A. Wickström106, Sebastian Brunemeier107, Sergey Jakimov57, Shan Luo108, Sharon Rosenzweig-Lipson66, Shih-Yin Tsai109, Stefanie Dimmeler110, Thomas A. Rando111, Tim R. Peterson112, Tina Woods113,114, Tony Wyss-Coray75, Toren Finkel115, Tzipora Strauss116,117, Vadim N. Gladyshev7, Valter D. Longo118, Varun B. Dwaraka119, Vera Gorbunova120, Victoria A. Acosta-Rodríguez121, Vincenzo Sorrentino14, Vittorio Sebastiano122, Wenbin Li123, Yousin Suh124, Alex Zhavoronkov20, Morten Scheibye-Knudsen79, Daniela Bakula79
  • 1Institute of Advanced Biotechnology and School of Medicine, Southern University of Science and Technology, Shenzhen, China
  • 2Max Planck Institute for Biology of Ageing, Cologne, Germany
  • 3Institute of Aging Medicine, College of Pharmacy, Binzhou Medical University, Yantai, China
  • 4Anti-aging Innovation Center, Subei Research Institute at Shanghai Jiaotong University, China
  • 5Shandong Cellogene Pharmaceutics Co. LTD, Yantai, China
  • 6Duke Kunshan University, Kunshan, Jiangsu, China
  • 7Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02108, USA
  • 8Foresight Institute, San Francisco, CA 91125, USA
  • 9Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
  • 10Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia
  • 11Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK
  • 12Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia
  • 13HautAI OÜ, Tallinn, Estonia
  • 14Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  • 15California Institute of Technology, Pasadena, CA 91125, USA
  • 16Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • 17Max Delbrück Center for Molecular Medicine, Berlin, Germany
  • 18The Kennedy Institute of Rheumatology, Oxford, UK
  • 19Department of Genetics, Stanford University, Stanford, CA 94305, USA
  • 20Insilico Medicine AI Limited, Level 6, Masdar City, Abu Dhabi, UAE
  • 21Systems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania
  • 22America's Frontier Fund, VA 23320, USA
  • 23Department of Biology, School of Science, Center for Developmental and Regenerative Biology, Indiana University - Purdue University Indianapolis, Indianapolis Indiana 46077, USA
  • 24Centre for Physical Activity Research, Rigshospitalet and University of Copenhagen, Denmark
  • 25Institute for Genome Stability in Aging and Disease, CECAD Research Center, University and University Hospital of Cologne, Cologne 50931, Germany
  • 26199 Biotechnologies Ltd., London, UK
  • 27University College London, London, UK
  • 28Molecular, Cellular, And Integrative Physiology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA 90095, USA
  • 29Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
  • 30Hong Kong Quantum AI Lab, Hong Kong
  • 31Zucker School of Medicine at Hofstra/Northwell, NY 10001, USA
  • 32Charité - University Medicine, Berlin, Germany
  • 33Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA
  • 34Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA
  • 35Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach CH-8603, Switzerland
  • 36Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA
  • 37Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA
  • 38Endocrinology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA
  • 39Leibniz Institute on Aging, Fritz Lipmann Institute, Friedrich Schiller University, Jena, Germany
  • 40Longevity Center Europe, Warsaw, Poland
  • 41Centre for Psychedelic Research, Dpt Brain Sciences, Imperial College London, UK
  • 42Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 02108, USA
  • 43Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN 55902, USA
  • 44School of Biology and Environmental Science, Belfield, Univeristy College Dublin, Dublin 4, Ireland
  • 45BioAge Labs, Richmond, CA 94530, USA
  • 46Buck Institute for Research on Aging, Novato, CA 94945, USA
  • 47Research and Early Development, Maaleov 2760, Denmark
  • 48VitaDAO, Ottawa, ON K1V 9K6, Canada
  • 49Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
  • 50Department of Medical Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  • 51Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen 2200, Denmark
  • 52Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen N 2200, Denmark
  • 53European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
  • 54Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong SAR, China
  • 55Rejuveron Life Sciences AG, 8952 Schlieren, Switzerland
  • 56Health, Nutrition and Care, DSM-Firmenich, Kaiseraugst, Switzerland
  • 57LongeVC, Riga, Latvia
  • 58InsideTracker, Cambridge, MA 02114, USA
  • 59Department of Psychiatry, Columbia University, New York, NY 10012, USA
  • 60Maxwell Biosciences, Austin, TX 73301, USA
  • 61Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
  • 62Cambrian Bio, Inc., New York, NY 10012, USA
  • 63XPRIZE Foundation, Culver City, CA 90230, USA
  • 64Department of Genetics Albert Einstein College of Medicine, New York, NY 10461, USA
  • 65Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • 66Life Biosciences, Boston, MA 02116, USA
  • 67Tornado Therapeutics, Cambrian Bio Inc. PipeCo, New York, NY 10012, USA
  • 68Department of Physiology and Biomedical Engineering and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA
  • 69Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19019, USA
  • 70Retro Biosciences, Inc., Redwood City, CA 94061, USA
  • 71Center on the Biology of Aging, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02860, USA
  • 72Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
  • 73Private Medical, San Francisco, CA 94107, USA
  • 74Faculty of Health Sciences Brandenburg and Faculty of Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg 01968, Germany
  • 75Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
  • 76Ichor Life Sciences, Inc., LaFayette, NY 13084, USA
  • 77Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
  • 78Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55414, USA
  • 79Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark
  • 80Nature Biotechnology, Springer Nature, London, UK
  • 81Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21201, USA
  • 82Rubedo Life Sciences, Sunnyvale, CA 94043, USA
  • 83Turn Biotechnologies, Mountain View 94039, CA, USA
  • 84Phaedon Institute, Oakland, CA 94501, USA
  • 85Institute of Biochemistry of the Romanian Academy, Romania
  • 86Fertility and Research Centre, Discipline of Women's Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia
  • 87Longevity Biotech Fellowship, Longevity Acceleration Fund, Vitalism, SF Bay, CA 94101, USA
  • 88Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117608, Singapore
  • 89Boston Consulting Group, Boston, MA 02210, USA
  • 90Leibniz-Institut Für Analytische Wissenschaften-ISAS-E.V., Dortmund, Germany
  • 91Repair Biotechnologies, Inc., Syracuse, NY 13210, USA
  • 92Sapere Bio, Triangle Research Park, NC 27213, USA
  • 93Holmusk, New York, NY 10012, USA
  • 94AniBiome, Zagreb, Croatia
  • 95Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10452, USA
  • 96Molecule, Neuhausen am Rheinfall, Switzerland
  • 97Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology, and Biochemistry, University of Minnesota, Minneapolis, MN 55111, USA
  • 98Gero PTE, Singapore, Singapore
  • 99Insilico Medicine Canada Inc., Montreal, Quebec H3B 4W8 Canada
  • 100Altos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA
  • 101Translational Gerontology Branch, Intramural Research Program, National Institute on Aging (NIH), Baltimore, Maryland 21201, USA
  • 102Huxley Building, School of Applied Sciences, University of Brighton, Brighton, UK
  • 103Biolytica, Zug, Switzerland
  • 104Deciduous Therapeutics, San Francisco, CA 94107, USA
  • 105Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm 10691, Sweden
  • 106Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany
  • 107Healthspan Capital, El Cerrito, CA 94530, USA
  • 108School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
  • 109Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  • 110Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Germany
  • 111Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA
  • 112Bioio, Inc., St. Louis, MO 63110, USA
  • 113Collider Heath, London, UK
  • 114Healthy Longevity Champion, National Innovation Centre for Ageing, UK
  • 115Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15106, USA
  • 116Sheba Longevity Center, Sheba Medical Center, Tel Hashomer, Israel
  • 117Tel Aviv Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • 118Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90001, USA
  • 119TruDiagnostic, Lexington, KY 40503, USA
  • 120Department of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA
  • 121Department of Neuroscience, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
  • 122Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94301, USA
  • 123Department of Neuro-Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
  • 124Department of Obstetrics and Gynecology, Columbia University, New York City, NY 10032, USA
  • 125Duke University, Durham, NC, USA
  • 126Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany
* Equal contribution
Received: July 3, 2024Accepted: July 23, 2024Published: October 16, 2024

Copyright: © 2024 Lyu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.