Correction|Volume 18|pp 813—814

Correction for: miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts

Wei-Ting Chang^1,^2,³, Jhih-Yuan Shih^2,⁴, Yu-Wen Lin¹, Tzu-Ling Huang¹, Zhih-Cherng Chen¹, Chi-Long Chen^5,⁶, Jan-Show Chu^5,⁶, Ping Yen Liu^1,⁷

¹Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
²Department of Internal Medicine, Division of Cardiology, Chi-Mei Medical Center, Tainan, Taiwan
³Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan
⁴Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
⁵Department of Pathology, College of Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan
⁶Department of Pathology, Taipei Medical University Hospital, Taipei, Taiwan
⁷Department of Internal Medicine, Division of Cardiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Received: February 7, 2026Accepted: June 26, 2026Published: July 8, 2026

https://doi.org/10.18632/aging.206404

Copyright: © 2026 Chang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

This article has been corrected: The authors have identified an unintentional error in Figure 5B affecting the baseline systolic blood pressure (SBP) values in the aging group. Specifically, Day 0 values from the young cohort were mistakenly assigned to the aged group panel during data plotting. The corresponding author, Dr. Wei-Ting Chang, has confirmed that all raw measurements were generated directly from the acquisition system and remain intact, and submitted it to the journal. After re-exporting the original machine-generated data and reconstructing the figure, the corrected panel now accurately reflects the underlying data. This correction does not affect the statistical analyses, results, or conclusions of the study. The authors have expressed their sincere apologies for this oversight.

The corrected Figure 5 is presented below.

Figure 5. The treatment of miR-21 antagomir mitigated angiotensin II (Ang II)-induced cardiac hypertrophy, especially in the aged mice. (A) The study design investigating the effects of miR-21 antagomir in young (12 week-old) and aged mice (50 week-old) of Ang II-induced pressure overload. The sequential changes of (B) systolic, (C) diastolic blood pressures, echocardiography derived (D) intraventricular septal thickness at diastole (IVSd), and (E) fractional shortening (FS) in young and old mice treated with miR-21 antagomir or not under Ang II-induced pressure overload. (F) The comparison of harvested hearts in mice of control, Ang II, miR-21 antagomir and Ang II+ miR-21 antagomir. ^*P < 0.05 for difference from each group (N = 4–6).