Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis

Natsu Yoshida; Yuko Maejima; Udval Sedbazar; Akihiko Ando; Hideharu Kurita; Boldbaatar Damdindorj; Eisuke Takano; Darambazar Gantulga; Yusaku Iwasaki; Tomoyuki Kurashina; Tatsushi Onaka; Katsuya Dezaki; Masanori Nakata; Masatomo Mori; Toshihiko Yada

doi:doi:10.18632/aging.100207

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Research Paper Volume 2, Issue 11 pp 775—784

Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis

Figure 1. Dual immunofluorescence histochemistry for nesfatin-1 and tyrosine hydroxylase (TH). (A-C) Neurons immunoreactive (IR) to nesfatin-1 (green) (A) and TH (red) (B), and their merged image (C) in the LC. (D-F) Neurons IR to nesfatin-1 (green) (D) and TH (red) (E), and their merged image (F) in the NTS. Colocalization of nesfatin-1 with TH is seen by yellow color in (C) and (F). Scale bar, 100 μm. 4V, forth ventricle.