Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis

Natsu Yoshida; Yuko Maejima; Udval Sedbazar; Akihiko Ando; Hideharu Kurita; Boldbaatar Damdindorj; Eisuke Takano; Darambazar Gantulga; Yusaku Iwasaki; Tomoyuki Kurashina; Tatsushi Onaka; Katsuya Dezaki; Masanori Nakata; Masatomo Mori; Toshihiko Yada

doi:doi:10.18632/aging.100207

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Research Paper Volume 2, Issue 11 pp 775—784

Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis

Figure 3. c-Fos expressions in several brain areas after icv administration of nesfatin-1. The number of c-Fos was significantly greater in the group treated with icv nesfatin-1 (0.5 nmol / 5 μl) than in control saline-treated group in the PVN (A,H), SON (B,H), NTS (D,H), LC (E,H), DR (F,H) and MR (G,H), while no difference was observed between two groups in the ARC (C,H). *p < 0.05, **p < 0.01 vs. control.