Research Paper Volume 2, Issue 12 pp 981—989
CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits
Figure 2. CD36 deficiency leads to BM thickening. Transmission electron microscopy of RPE/sub-RPE region in 4 months (mo)-old CD36+/+ (A) and CD36−/− (C) showed similar BM thickness; arrowhead points to Bruch's membrane (BM). While, 12-month-old CD36+/+ (B) and CD36−/− mice (D) reveal increased BM thickness and nodular debris (asterix) in BM of CD36−/− subjects (D). BM average (E) and maximal (F) thickness in CD36+/+ and CD36−/− mice at 4 and 12 months of age. RPE refers to retinal pigment epithelium. Scale bar: 1μm. Values are mean ± SEM; n=5/group. * p<0.01 compared to values without asterisks.