Research Paper Volume 2, Issue 12 pp 914—923

Figure 1. SIRT3 prevents mitochondrial permeability transition in cardiac tissue during aging. Mitochondrial swelling induced by Ca²⁺. Mitochondria from 3 (A), 6 (B) and 16 months old (C) wt and SIRT3^−/− mouse hearts subjected to Ca²⁺-induced mitochondrial swelling, measured as % decrease in the initial optical density (OD540) in the presence or absence of 1 μM CsA (n=4 per group and age). All error bars show s.e.m.