Research Paper Volume 3, Issue 4 pp 407—416

Figure 3. Dermabrasion restores young adult fibroblast function in geriatric dermis. A 5 cm² area of sun-protected skin on geriatric (≥65 years old) volunteers was dermabraded. After a healing period of three months, biopsies of untreated and dermabraded skin were obtained. (A) Representative H&E sections from untreated and dermabraded geriatric skin. Panels i and iv are higher magnification images of dark boxes indicated in panels ii and v. Panels iii and vi are higher magnification images of light boxes indicated in panels ii and v. Panels i and iv, bar = 10 µm; panels ii and v, bar = 50 µm; panels iii and vi, bar = 12.5 µm. (B) The area of epidermis and papillary dermis were calculated as described in Fig. 2. Asterisk indicates statistical significance from geriatric control values (Epidermis p = 0.287, Papillary dermis p = 0.013; two-tailed t-test). (C) The number of senescent fibroblasts in the papillary dermis was determined as described in Fig. 2. Asterisk indicates statistical significance from control values (p = 0.018, two-tailed t-test).