Research Perspective Volume 3, Issue 6 pp 635—642
SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2
Figure 2. Regulation of homologous enzymes by sirtuins SIRT1 and SIRT3. SIRT1 deacetylates acetyl-CoA synthetase 1 (AceCS1) and 3-hydroxy-3-methylglutaryl CoA synthase 1 (HMGCS1) in the cytoplasm. SIRT3 deacetylates acetyl-CoA synthetase 2 (AceCS2) and 3-hydroxy-3-methylglutaryl CoA synthase 2 (HMGCS2) in the mitochondrial matrix.