Research Paper Volume 4, Issue 7 pp 456—461

Figure 3. The scheme summarizes the stretch-induced pathway that allows ROS scavenging in response to mechanical stimuli. As previously described, stretch–dependent transcriptional activation of Sirt1 by EGR1 activates the Sod2 gene by stimulating FOXO binding to the Sod2 promoter leading to lowering ROS content to its basal levels [6]. The interaction between EGR1 and SIRT1 prevents EGR1 binding to the Sirt1 promoter triggering an autoregularoty loop that turns down SIRT1 expression from the stretch-induced to basal levels.