Research Paper Volume 4, Issue 9 pp 648—659
Increased IL-21 secretion by aged CD4+T cells is associated with prolonged STAT-4 activation and CMV seropositivity
Figure 2. IL-21 secretion is increased from CD4+ T cells from aged subjects. A, B, C Bar graph depicts the levels of IL-21 (A), IFN-γ (B), IL-17 (C) in the supernatant from aged and young total CD4+ T cells after stimulation with IL-12 for 5 days. Data is mean +/− S.E. of 23 different aged and young subjects. D, F. Bar graph depicts the levels of IL-21 secreted from aged and young, Naïve CD4+ T cells (D) and memory CD4+ T cells (F) after stimulation with IL-12 for 5 days. E, G. Bar graph depicts the levels of IL-21 secreted from aged and young, Naïve CD4+ T cells (E) and memory CD4+ T cells (G) after stimulation with IL-12 for 5 days. Data is mean +/− S.E. of 15 different aged and young subjects.