Research Paper Volume 4, Issue 11 pp 755—767

Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease

Figure 1. The effect of the GHRH antagonist, MIA-690, on the progressive changes of the behavioral parameters of the 5XFAD transgenic mice in Morris water maze (MWM) experiments. Mice were treated with daily subcutaneous injections of GHRH antagonist MIA-690 at doses of 2, 5, and 10 μg for 6 months. The pooled standard errors (PSE)s of the groups were the following (A) control: 36.0, MIA-690 (2 μg): 41.2, MIA-690 (5 μg): 33.3, MIA-690 (10 μg): 36.9; (B) control: 21.8, MIA-690 (2 μg): 31.4, MIA-690 (5 μg): 20.6, MIA-690 (10 μg): 16.0; (C) control: 53.1, MIA-690 (2 μg): 63.4, MIA-690 (5 μg): 51.9, MIA-690 (10 μg): 38.0; (D) control: 43.6, MIA-690 (2 μg): 74.6, MIA-690 (5 μg): 45.3, MIA-690 (10 μg): 40.0. * = p < 0.05 vs. control according to repeated measure general linear model analysis.