Research Paper Volume 4, Issue 11 pp 755—767

Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease

Figure 3. The effect of MIA-690 on the behavioral parameters of the 5XFAD transgenic mice in the spatial acquisition of the MWM experiments, during the 1st and 6th month. Mice were treated with daily subcutaneous injections of GHRH antagonist MIA-690 at doses of 2, 5, and 10 μg for 6 months. The pooled standard errors (PSE)s of the groups were the following (A) control: 28.32, MIA-690 (2 μg): 44.1, MIA-690 (5 μg): 25.5, MIA-690 (10 μg): 37.6; (B) control: 30.8, MIA-690 (2 μg): 47.4, MIA-690 (5 μg): 25.0, MIA-690 (10 μg): 43.2; (C) control: 20.1, MIA-690 (2 μg): 15.9, MIA-690 (5 μg): 17.6, MIA-690 (10 μg): 28.6; (D) control: 22.0, MIA-690 (2 μg): 16.6, MIA-690 (5 μg): 19.8, MIA-690 (10 μg): 23.5. * = p < 0.05 vs. control according to repeated measure general linear model analysis.