Research Paper Volume 5, Issue 8 pp 607—622
Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production
Figure 4. Assessing DNA repair and senescence markers in cerebral cortex. (A) Immunoblot images of DNA double strand break repair (Ku70, Ku80, and DNAPKcs), and senescence and DNA damage response (p19, p16, p21, p53, Bax, and Bcl2) proteins two and twelve months after radiation. (B) Quantification of Ku70, Ku80, and DNAPKcs two months after radiation. (C) Quantification of Ku70, Ku80, and DNAPKcs twelve months after radiation. (D) Quantification of p19, p16, p21, p53, Bax, and Bcl2 two months after radiation. (E) Quantification of p19, p16, p21, p53, Bax, and Bcl2 twelve months after radiation. Quantification data (panel B to E) is presented as mean ± SEM.