Research Paper Volume 5, Issue 12 pp 925—938

Plasma microRNA biomarkers for detection of mild cognitive impairment: Biomarker Validation Study


Figure 4. Receiver-Operating Characteristic (ROC) curve analysis of differentiation between MCI patients and age-matched controls obtained with different biomarker pairs in male (a, b) and female (c, d) cohorts. The areas under the ROC curve (AUC), sensitivity, specificity and accuracy for each biomarker/normalizer pair presented in Table 3 are calculated for the “cutoff” point – the value of the ratio of paired miRNA where the accuracy of predictions is the highest.