Research Paper Volume 7, Issue 11 pp 1004—1021

Improved motor and cognitive performance with sodium nitrite supplementation is related to small metabolite signatures: a pilot trial in middle-aged and older adults


Figure 2. Rate of torque development (RTD) for the knee extensors at baseline and following 10 weeks of placebo (white) or sodium nitrite supplementation (gray – 80 mg/day; black – 160 mg/day). Sodium nitrite supplementation improved knee extensor RTD as shown by time × treatment interaction for three groups (A); * p<0.05). Individual subject data (B) indicated that knee extensor RTD changed little across 10 weeks for placebo (white circles), but improved for most subjects taking sodium nitrite 80 mg/day (gray circles), and subjects supplemented with 160 mg/day (black circles).