Research Paper Volume 7, Issue 12 pp 1094—1108

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

Figure 5. Changes in β-CATENIN signaling in hippocampus of 4-, 12- and 24-month-old rats. (A) Representative Western blotting autoradiographs of cytosolic βCATENIN/αTUBULIN and pβCATENIN/βCATENIN. (B) Densitometric analysis (arbitrary units) of βCATENIN/αTUBULIN and pβCATENIN/βCATENIN ratios of data presented in A panel are shown. Results are expressed as mean ± S.E.M. from three individual experiments. ANOVA followed by Newman-Keuls. (a) p<0.05 vs. 4-month-old basal sample, (b) p<0.05 vs. 12-month-old basal sample. (C) Representative Western blotting autoradiographs of nuclear β-CATENIN and α-TUBULIN. (D) Densitometric analysis (arbitrary units) of β-CATENIN/α-TUBULIN ratio of data presented in C panel is shown. Results are expressed as mean ± S.E.M. from three individual experiments. ANOVA followed by Newman-Keuls. (a) p<0.05 vs. 4-month-old basal sample, (b) p<0.05 vs. 12-month-old basal sample.