Research Paper Volume 8, Issue 3 pp 458—483

Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo−/− mice

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Figure 5. Correlation of median life span and serum ascorbate levels in Gulo−/− mice with different metabolites and cytokines.

(A) Correlation between alpha-AAA and sE-selectin with a r > 0.99 and a P-value < 0.01 in our mouse cohorts. (B) Correlation between 6-keto-PGF1a and PAI-1 with a r > 0.99 and a P-value < 0.01 in our mouse cohorts. (C) Graphs showing the correlation between the median life span of mice and serum ascorbate level. (D) Correlation between serum ascorbate and resistin. (E) Correlation between serum acylcarnitine C18:2 and median life span. (F) Correlation between resistin and median life span. The Pearson's correlation r values and P-values are indicated on each graph.