Research Paper Volume 8, Issue 4 pp 697—708
Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus – an aging connection
Figure 3. Oxidative DNA damage in the PFC and hippocampus tissues of chemotherapy-exposed animals. (A) Levels of 8-oxo-7-hydrodeoxyguanosine (8-oxodG) in genomic DNA isolated from the PFC and hippocampus of male and female mice (mean ± SD, n=4); *p<0.05, Student's t-test. (B) Levels of APE1 and OGG1 in the PFC tissues of chemotherapy-exposed female animals 3 weeks after treatment. Lysates from PFC tissues were immunoblotted using antibodies against APE1, OGG1 and actin. *p<0.05, Student's t-test.