Retinoic acid treated human dendritic cells induce T regulatory cells via the expression of CD141 and GARP which is impaired with age

Sudhanshu Agrawal; Sreerupa Ganguly; Alexander Tran; Padmaja Sundaram; Anshu Agrawal

doi:doi:10.18632/aging.100973

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Research Paper Volume 8, Issue 6 pp 1223—1235

Retinoic acid treated human dendritic cells induce T regulatory cells via the expression of CD141 and GARP which is impaired with age

Figure 3. CD141 and GARP co-localize in RA treated DCs. DCs from aged and young subjects were treated overnight with RA. The expression of GARP and CD141 on gated CD11c DCs was determined by flow cytometry. (A) Dot plot depicts the expression of CD141 and GARP on DCs and the percentages of CD141^hiGARP⁺ and CD141^lo GARP⁻ DCs. (B) Images depict the co-localization of CD141 and GARP after RA exposure of DCs as determined by Imagestream. BF-brightfield image; Merged is CD141/GARP. Representative of 3 such experiments.