SIRT6 protects against endothelial dysfunction and atherosclerosis in mice

Suowen Xu; Meimei Yin; Marina Koroleva; Michael A. A. Mastrangelo; Wenbo Zhang; Peter Bai; Peter J. J. Little; Zheng Gen Gen Jin

doi:doi:10.18632/aging.100975

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Research Paper Volume 8, Issue 5 pp 1064—1078

SIRT6 protects against endothelial dysfunction and atherosclerosis in mice

Figure 1. Global deletion of SIRT6 impairs endothelium-dependent relaxation. (A) Schematic diagram of the transgenic mice used to generate SIRT6^−/− mice. (B) Western blot analysis showing SIRT6 protein expression in aortic lysates from SIRT6^+/+, SIRT6^+/−, and SIRT6^−/− mice, n = 4. (C) Vascular reactivity of WT (SIRT6^+/+), SIRT6^+/− and SIRT6^−/− aortic rings to acetylcholine (Ach), ***P<0.001, compared to Sirt6+/+ littermates, n = 8-10; (D) Vascular reactivity of WT, SIRT6^+/− and SIRT6^−/− aortic rings to sodium nitroprusside (SNP), n=6-8.