Research Paper Volume 8, Issue 8 pp 1593—1606

Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

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Figure 8. Bedaquiline has little or no effect on the viability of MCF7 cancer cells and normal human fibroblasts. Bedaquiline (5μM and 10 μM) treatment of MCF7 cells and hTERT-BJ1 normal human fibroblasts was carried out for 5 days. The SRB assay was performed as a measure of cell viability. (A, B) Bedaquiline has little or no inhibitory effects on the viability of MCF7 cells and human fibroblasts. **** p<0.00001, ns not significant.