Telomerase and estrogen-sensing activities are essential for continued mammary growth <i>in vivo</i> but dispensable for “reprogramming” neural stem cells

Andrea L. L. George; Corinne A. A. Boulanger; Gilbert H. H. Smith

doi:doi:10.18632/aging.100985

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Research Paper Volume 8, Issue 7 pp 1353—1362

Telomerase and estrogen-sensing activities are essential for continued mammary growth in vivo but dispensable for “reprogramming” neural stem cells

Figure 1. Shortened telomeres lead to enhanced mammary gland senescence upon serial transplantation. Whole mounted glands from TER^+/+ (A-C), TER^+/− (D-F), and TER^−/− (g1 G-I, g5 J-L) transplanted tissues from early transplant generations 1 and 2 (A,D,G,J), middle transplant generation 3 (B, E, H, K), and late transplant generations 4 and 5 (C, F, I, L). Scale bars: 2mm.