Telomerase and estrogen-sensing activities are essential for continued mammary growth <i>in vivo</i> but dispensable for “reprogramming” neural stem cells

Andrea L. L. George; Corinne A. A. Boulanger; Gilbert H. H. Smith

doi:doi:10.18632/aging.100985

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Research Paper Volume 8, Issue 7 pp 1353—1362

Telomerase and estrogen-sensing activities are essential for continued mammary growth in vivo but dispensable for “reprogramming” neural stem cells

Figure 2. Senescent mammary cells “reprogram” neuronal stem cells in vivo. Whole mount picture (A) of chimeric outgrowth from TGF-β1⁺ mammary cells (100k) and NSCs (50k) and (B) cross section of mammary glands from TER+/− mammary cells (50K) and NSCs (50k). Positive LacZ staining in outgrowths verified NSC incorporation.