Research Paper Volume 8, Issue 12 pp 3185—3208
Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging
Figure 6. Bcl-xL, decreases senescence and enhances proliferation in lymphocytes from septuagenarian individuals in primary culture. (a) Bcl-xL over-expression in lymphocytes from septuagenarian individuals. (b) Bcl-xL down-regulates the expression of age-associated cell cycle inhibitors p16Ink4a, p14Arf, and p21CIP in septuagenarian PBMCs transduced with Bcl-xL (n=3). (c) Representative pictures (left) and quantification of sphere formation (right) of PHA-stimulated lymphocytes infected with Bcl-xL or the empty vector (n=2).